Thymosin Beta 4 TB500 (5mg)

Description

Thymosin Beta 4 (TB-500, 5mg) is the research-entry quantity of the 43-amino acid actin-sequestering peptide first isolated from bovine thymus by Low and Goldstein. TB4 is one of the most abundant intracellular peptides in eukaryotic cells, where it maintains the pool of unpolymerized G-actin by forming a 1:1 complex with actin monomers. The 5mg quantity supports preliminary mechanism studies and dose-finding experiments.

Why Researchers Select TB4

Beyond its structural role in cytoskeletal dynamics, TB4 promotes cell migration, differentiation, and angiogenesis by upregulating integrin-linked kinase (ILK) and activating downstream pathways including PI3K/Akt. Published studies have examined TB4 in wound healing acceleration, cardiac progenitor cell activation, and corneal repair models. The active tetrapeptide fragment Ac-SDKP — cleaved from TB4 by prolyl oligopeptidase — is independently studied for anti-fibrotic and angiogenic effects.

Common Research Applications

• Actin cytoskeletal dynamics and G-actin sequestration studies
• Cell migration and wound healing mechanism research
• ILK/PI3K/Akt pathway modulation studies
• Angiogenesis promotion in in vitro models
• Cardiac and tissue repair pathway investigation

Molecular Profile

• MW: ~4,964 g/mol | CAS: 77591-33-4 | Purity: ≥98% HPLC

For Research Use Only. Not for human or veterinary use.