SS-31 (10mg)

Description

SS-31 (10mg) (Elamipretide; D-Arg-2,6-dimethyl-Tyr-Lys-Phe-NH₂) is a mitochondria-targeted tetrapeptide developed by Hazel Szeto and Peter Schiller. It is designed to penetrate the inner mitochondrial membrane (IMM) and interact specifically with cardiolipin — the signature phospholipid of the IMM that is essential for electron transport chain (ETC) organization and ATP synthase function.

Why Researchers Select SS-31 (10mg)

Cardiolipin is uniquely concentrated in the IMM and stabilizes ETC complexes I, III, IV and ATP synthase in their active configurations. In aging and disease models, cardiolipin undergoes oxidation and remodeling, disrupting ETC efficiency and increasing mitochondrial ROS. SS-31 (10mg) binds selectively to cardiolipin (via electrostatic interaction), stabilizes ETC supercomplex architecture, reduces electron leak, and decreases mitochondrial ROS production — making it the primary reference compound for studying cardiolipin-ETC interactions and mitochondrial quality. The 10mg format suits in vitro and small-scale in vivo mechanistic studies.

Common Research Applications

• Cardiolipin-ETC supercomplex stabilization research
• Mitochondrial ROS reduction and oxidative stress models
• ATP synthesis efficiency studies
• Ischemia-reperfusion injury mitochondrial protection
• Age-related mitochondrial dysfunction models

Molecular Profile

• Sequence: D-Arg-2,6-dimethylTyr-Lys-Phe-NH₂ | MW: ~639.8 g/mol
• CAS: 736992-21-5 | Purity: ≥98% HPLC

For Research Use Only. Not for human or veterinary use.