LYSINE-PROLINE-VALIVE (10mg)

Description

Lysine-Proline-Valine (KPV) is a C-terminal tripeptide fragment of α-melanocyte-stimulating hormone (α-MSH) that retains the anti-inflammatory and antimicrobial properties of the parent peptide without its melanocortin receptor agonist activity. KPV acts through intracellular NF-κB pathway inhibition and has been specifically studied for its effects on gut epithelial inflammation and barrier function in mucosal research models.

Why Researchers Select KPV

While full-length α-MSH and its derivatives (Melanotan II, PT-141) exert their effects through melanocortin receptor agonism, KPV bypasses this pathway and acts through receptor-independent NF-κB inhibition — making it specifically useful for studying anti-inflammatory mechanisms in receptor-knockout models or when MCR activation is a confounding variable. In gut biology, KPV has been studied for its ability to reduce IL-8, TNF-α, and IL-1β expression in intestinal epithelial cells, and to maintain tight junction integrity under inflammatory challenge, positioning it as a research tool for IBD pathway investigation.

Common Research Applications

• NF-κB pathway inhibition and anti-inflammatory mechanism studies
• Gut epithelial barrier function and tight junction integrity research
• IBD and intestinal inflammation pathway investigation
• α-MSH C-terminal fragment bioactivity characterization
• Receptor-independent anti-inflammatory peptide mechanism studies

Molecular Profile

• Sequence: Lys-Pro-Val | MW: ~341.4 g/mol | Purity: ≥98% HPLC | Form: Lyophilized powder

For Research Use Only. Not for human or veterinary use.