CJC-1295 Without DAC (10mg)

Description

CJC-1295 Without DAC (also designated Mod-GRF 1-29) is a modified fragment of growth hormone-releasing hormone (GHRH) consisting of the first 29 amino acids with four amino acid substitutions at positions 2, 8, 15, and 27. These modifications improve metabolic stability without extending half-life artificially, producing a pulsatile GH release pattern that closely mirrors endogenous GHRH secretion dynamics.

Why Researchers Select CJC-1295 Without DAC

Unlike the DAC version — which uses a drug affinity complex to extend half-life to 6–8 days — Mod-GRF 1-29 produces short, physiological GH pulses aligned with the natural somatotroph secretory pattern. This makes it the preferred format for researchers studying GH pulse amplitude, frequency dynamics, and GHRH receptor kinetics without the prolonged receptor occupancy introduced by the DAC modification. The 10mg quantity supports extended multi-session or multi-arm study protocols.

Common Research Applications

• Physiological GH pulsatility and GHRH receptor pharmacology
• Somatotroph response characterization under controlled conditions
• GH/IGF-1 axis investigation
• Comparative GHRH analogue studies
• GH secretagogue combination protocols (with GHSR agonists)

Molecular Profile

• MW: ~3,368 g/mol | CAS: 863288-34-0 | Purity: ≥98% HPLC

For Research Use Only. Not for human or veterinary use.