SLU-PP-332 (5mg)

Description

SLU-PP-332 is a small-molecule pan-agonist of the estrogen-related receptor (ERR) family — specifically ERRα, ERRβ, and ERRγ — developed at Saint Louis University. It acts as an exercise mimetic by activating ERR-driven transcriptional programs that overlap significantly with the gene expression changes induced by aerobic exercise in skeletal muscle and other metabolic tissues.

Why Researchers Select SLU-PP-332

ERRα, ERRβ, and ERRγ are orphan nuclear receptors that regulate mitochondrial biogenesis, fatty acid oxidation, oxidative phosphorylation, and muscle fiber type specification. By pan-activating all three ERR family members simultaneously, SLU-PP-332 induces a broad transcriptional response that mirrors exercise-induced metabolic adaptation: increased mitochondrial content, enhanced oxidative capacity, and improved metabolic flexibility — without physical activity. Published studies demonstrated improvements in treadmill endurance in sedentary mice and cardiac protection in heart failure models. This makes SLU-PP-332 a significant tool for studying exercise biology, metabolic disease, and heart failure independently of activity confounders.

Common Research Applications

• ERR family (ERRα/β/γ) agonism and transcriptional regulation studies
• Exercise mimetic and mitochondrial biogenesis research
• Skeletal muscle metabolism and fiber type specification
• Heart failure and cardiac energetics investigation
• Metabolic flexibility and fat oxidation studies

Molecular Profile

• Type: Small molecule ERR pan-agonist | Purity: ≥98% HPLC | Form: Lyophilized powder

For Research Use Only. Not for human or veterinary use.