Selank (10mg)

Description

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide anxiolytic developed at the Institute of Molecular Genetics (Russian Academy of Sciences) based on the immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg). The appended Pro-Gly-Pro tripeptide stabilizes the molecule against enzymatic degradation while modifying its activity profile from purely immunological to include significant GABAergic and neurotrophic effects.

Why Researchers Select Selank

Selank modulates GABA-A receptor function and increases GABA levels in the hippocampus and amygdala in animal models — producing anxiolytic effects through a mechanism distinct from benzodiazepines (no receptor agonism, no tolerance induction in rodent studies). It also upregulates BDNF and influences IL-6 and interferon-γ expression, providing a dual neuroimmune research profile. Studies have investigated its effects on memory consolidation, fear extinction, and anxiety-related behavior in rodent models.

Common Research Applications

• GABAergic modulation and anxiety pathway research
• BDNF upregulation and neurotrophic signaling studies
• Fear extinction and memory consolidation models
• Neuroimmune interaction (IL-6, IFN-γ modulation)
• Tuftsin-derived peptide immunopharmacology research

Molecular Profile

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro | MW: ~751.9 g/mol | Purity: ≥98% HPLC

For Research Use Only. Not for human or veterinary use.