N-Acetyl Epitalon Amidate (5 mg)

Description

N-Acetyl Epitalon Amidate is a chemically stabilized variant of Epithalon (Ala-Glu-Asp-Gly) featuring acetylation at the N-terminus and amidation at the C-terminus. These modifications protect the peptide against aminopeptidase and carboxypeptidase enzymatic cleavage, significantly improving metabolic stability and in vitro half-life compared to the unmodified tetrapeptide — without altering the core AEDG sequence that mediates bioactivity.

Why Researchers Select N-Acetyl Epitalon Amidate

For researchers studying Epithalon’s effects on telomerase activation, circadian regulation, or aging biomarkers in cell culture or in vivo models where protease exposure is a concern, the acetyl-amide form provides greater experimental control. It reduces the variable of peptide degradation rate from experimental results, allowing cleaner dose-response relationships and more reproducible outcomes across longer incubation periods or in vivo pharmacokinetic studies.

Common Research Applications

• Telomerase activation studies requiring extended incubation stability
• Protease-rich environment aging model research
• Comparative pharmacokinetic studies vs. unmodified Epithalon
• In vivo longevity model studies requiring improved bioavailability

Molecular Profile

• Base sequence: Ala-Glu-Asp-Gly (AEDG) | Modifications: Ac-N-terminus; C-terminus amide
• Purity: ≥98% HPLC | Form: Lyophilized powder

For Research Use Only. Not for human or veterinary use.