KissPeptin (10mg)

Description

Kisspeptin-10 (KP-10) is the C-terminal decapeptide fragment of the kisspeptin family (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂) and the minimum active sequence required for full GPR54 receptor activation. The kisspeptin system was identified as the critical upstream regulator of gonadotropin-releasing hormone (GnRH) secretion, establishing it as a gatekeeper of reproductive neuroendocrinology.

Why Researchers Select KP-10

Kisspeptin neurons in the arcuate nucleus (KNDy neurons) and anteroventral periventricular nucleus integrate peripheral hormonal signals (estrogens, progesterone, testosterone, leptin) and relay them as pulsatile kisspeptin release onto GnRH neurons — making kisspeptin the central translator of metabolic and hormonal status into reproductive function. KP-10 is the standard tool compound for GPR54 stimulation studies due to its manageable size and well-characterized pharmacology, used to investigate the kisspeptin-GnRH-LH-FSH axis and its regulation by sex steroids.

Common Research Applications

• GPR54 receptor agonism and reproductive axis studies
• GnRH neuron activation and LH pulse research
• Kisspeptin-GnRH-gonadotropin (HPG) axis regulation
• Pubertal timing and sex steroid feedback models
• Metabolic-reproductive axis interaction research (leptin, insulin)

Molecular Profile

• Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂ | MW: ~1,302.5 g/mol
• CAS: 374683-28-0 | Purity: ≥98% HPLC

For Research Use Only. Not for human or veterinary use.