B12 (10ml)

Description

This B12 solution contains methylcobalamin — the neurologically active coenzyme form of vitamin B12 — supplied as a sterile research-grade solution. Unlike cyanocobalamin (the synthetic supplement form), methylcobalamin participates directly in one-carbon metabolism as the cofactor for methionine synthase without requiring hepatic conversion.

Why Researchers Select Methylcobalamin

Vitamin B12 is an essential cofactor for two enzymatic reactions: (1) remethylation of homocysteine to methionine via methionine synthase (methylcobalamin-dependent), and (2) isomerization of methylmalonyl-CoA to succinyl-CoA (adenosylcobalamin-dependent). Researchers studying one-carbon metabolism, homocysteine pathways, neurological myelination models, or DNA repair mechanisms include B12 as a key variable. Methylcobalamin is specifically selected for neurological models due to preferential CNS tissue penetration versus cyanocobalamin in in vivo settings.

Common Research Applications

• One-carbon metabolism and methylation cycle studies
• Homocysteine pathway research (methionine synthase activity)
• Neurological models (myelination, axonal integrity)
• DNA synthesis and megaloblastic anemia pathway studies
• Mitochondrial energy metabolism (succinyl-CoA pathway)

Specification

• Form: 10ml aqueous solution | Active: Methylcobalamin | Grade: Research-use sterile-filtered

Storage: 4°C; protect from light (highly photosensitive).

For Research Use Only. Not for human or veterinary use.