5-Amino-1MQ (5mg)
Original price was: $50.00.$39.00Current price is: $39.00.
5-Amino-1MQ (5mg) is a research-use product for laboratory studies involving metabolic pathways, energy-balance models, and structured workflow design.
Description
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that catalyzes the N-methylation of nicotinamide using S-adenosylmethionine (SAM) as the methyl donor. The 5mg quantity is suited for in vitro cell culture experiments, IC50 determination, or initial mechanism characterization.
Why Researchers Select 5-Amino-1MQ
NNMT is highly expressed in adipose tissue and upregulated in obesity and type 2 diabetes models. By inhibiting NNMT, 5-Amino-1MQ increases intracellular SAM availability and shifts the NAD⁺/NADH ratio — producing a measurable metabolic effect in adipocyte and hepatocyte models. Published cell studies have demonstrated that NNMT inhibition reduces triglyceride accumulation in 3T3-L1 adipocytes.
Common Research Applications
- NNMT inhibition in adipocyte differentiation models
- NAD⁺ metabolism and cellular energy regulation
- Metabolic syndrome and obesity pathway investigation
- Epigenetic methylation studies (SAM pool modulation)
- Mitochondrial function and thermogenesis research
Molecular Profile
- MW: ~179.6 g/mol | Form: Lyophilized powder | Purity: ≥99% HPLC
For Research Use Only. Not for human or veterinary use.
Additional information
| Weight | 0.2 lbs |
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