VIP10 (10mg)

Description

VIP10 is a 10-amino acid active fragment of Vasoactive Intestinal Peptide (VIP), the 28-amino acid neuropeptide originally isolated from porcine small intestine by Said and Mutt in 1970. VIP is one of the most widely distributed neuropeptides in the mammalian nervous system and acts through VPAC1 and VPAC2 receptors to regulate vasodilation, immune modulation, circadian rhythms, and neurotrophic activity. The 10-AA fragment retains key receptor-binding properties while providing a more metabolically stable and synthetically accessible research tool.

Why Researchers Select VIP10

VIP has broad research significance: it is the primary circadian output signal from the SCN (suprachiasmatic nucleus), a potent bronchodilator studied in pulmonary biology, a T-regulatory cell inducer studied in autoimmune research, and a neuroprotective peptide investigated in neurodegenerative models. The shorter VIP10 fragment reduces the complexity of full-length VIP synthesis while preserving VPAC receptor binding and key biological activities, making it practical for structure-activity relationship studies and mechanistic investigation.

Common Research Applications

• VPAC1/VPAC2 receptor pharmacology and binding studies
• Circadian rhythm and SCN output signal research
• Anti-inflammatory and T-regulatory cell modulation studies
• Pulmonary bronchodilation pathway investigation
• Neuroprotection and neurotrophic pathway research

Molecular Profile

• Type: VIP C-terminal active fragment (10 AA) | Purity: ≥98% HPLC | Form: Lyophilized

For Research Use Only. Not for human or veterinary use.