Neuro-Longevity

Description

The Neuro-Longevity Research Kit combines Epithalon (10mg), FOXO4-DRI (10mg), and NAD⁺ (500mg) — addressing three distinct mechanisms at the cellular aging-neural function interface: telomerase activation and replicative aging (Epithalon), senescent cell clearance (FOXO4-DRI), and NAD⁺-dependent sirtuin/PARP activity (NAD⁺).

Kit Components

• Epithalon (10mg): Tetrapeptide (Ala-Glu-Asp-Gly) activating telomerase (hTERT) in somatic cell models. Also modulates melatonin synthesis and circadian gene programs. Studied extensively in Khavinson’s biogerontology research program.
• FOXO4-DRI (10mg): D-amino acid retro-inverso senolytic peptide that disrupts FOXO4-p53 interaction, releasing p53 to activate mitochondrial apoptosis selectively in senescent cells. The primary peptide-based senolytic tool compound.
• NAD⁺ (500mg): Sirtuin substrate and PARP cofactor. Declining with age. Required for SIRT1-driven deacetylation that regulates gene expression, mitochondrial biogenesis, and DNA repair in longevity research.

Research Context

This kit covers the three primary cellular aging mechanisms studied in longevity biology: telomere shortening (Epithalon), cellular senescence accumulation (FOXO4-DRI), and NAD⁺ decline (NAD⁺). Researchers can study each mechanism independently or investigate interactions — for example, whether senescent cell clearance alters local NAD⁺ availability, or whether telomerase activation influences senescence burden.

Common Research Applications

• Three-mechanism cellular aging pathway research
• Telomere + senescence + NAD⁺ decline interaction studies
• Neural longevity and cognitive aging model investigation
• Senolytic + telomerase combination research

For Research Use Only. Not for human or veterinary use.